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Charcot-Marie-Tooth Disease

INTRO
CAUSES
SYMPTOMS
DIAGNOSIS
TREATMENTS OPTIONS
COMPLICATIONS
ORTHOFIX SOLUTIONS

Charcot-Marie-Tooth Disease

Charcot-Marie-Tooth disease (CMT) is a group of inherited neurological disorders involving the peripheral nerves – that is, those that are outside the brain and spinal cord, and govern the motor and sensory capabilities in the limbs (such as walking).2 Its estimated prevalence in the general population is 1 in 2,500 (.04%).

Pes normal
Normal Foot
Charcot-Marie-Tooth Disease
Charcot-Marie-Tooth Disease

Causes

CMT is caused by congenital mutations in genes involved with the structure and function of the nerves governing the feet, legs, hands and arms. There is no single faulty gene and there are many varieties of CMT caused by different genetic faults.

Symptoms

Usually develops between 5 and 15 years but may develop later. Foot deformities may occur, and the lower legs may have an “inverted champagne bottle” appearance as muscle bulk is lost. As the disease gradually progresses, weakness and loss of fine motor skills may occur, with pain ranging from mild to severe.2

Diagnosis

Examination by a neurologist will raise the possibility of the disease, which will be confirmed by nerve conduction studies, electromyography to measure the electrical activity of your muscles, and sometimes, in uncertain cases, by nerve biopsy.

Treatment Options

Although CMT cannot be cured, it can be managed with physical therapy, braces, pain medication and surgery.2 Osteotomy (the surgical cutting of a bone or removal of a piece of bone) and treatment with an external fixation device can help to reverse foot and joint deformities, aiding support and strength.2

Complications

Left untreated, CMT leads to pain and difficulties walking, which decrease everyday activity levels and in turn, adversely affects quality of life and further deteriorates mobility. Foot wounds, foot fractures and more-severe deformities of the foot and ankle may also occur.

Ankle Hindfoot Nailing System™

Important safety information: Download the Product Instructions For Use.

The Orthofix Ankle Hindfoot Nailing System (AHN) is designed to be used for the fusing and fixation of bones in the ankle.

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G-Beam™

Important safety information: Download the Product Instructions For Use.

In beaming, a large diameter cannulated device distributes the axial load of the bone between fixation points, which helps hold a joint or osteotomy until it heals.

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SOLE™ Medial Column Fusion Plate

Important safety information: Download the Product Instructions For Use.

The SOLE™ Medial Column Fusion Plate System consists of stainless steel plates and screws, and is designed for the fixation of small bones and joints in the foot. The plates and screws are made for complex reconstruction procedures like Charcot foot.

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TL-HEX TrueLok Hexapod System™

Important safety information: Download the Product Instructions For Use.

TL-HEX is a dynamic, 3D external fixation system that combines hardware and software to correct bone deformities. This hexapod-based system functions as a 3D bone segment-repositioning module. In essence, the system consists of circular and semi-circular external supports secured to the bones by wires and half-pins, interconnected by six struts.

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TrueLok™

Important safety information: Download the Product Instructions For Use.

The Ilizarov System has experienced many modifications over the last fifty years. The TrueLok™ Ring Fixation System, developed at Texas Scottish Rite Hospital for Children (TSRHC) in Dallas, Texas, is one of the modern variants of the original fixator, but preserves many of the original principles of Professor Ilizarov. It consists of aluminum rings available in different sizes, connected to the bone through metal wires or/and bone screws. The relative movements of the rings allow the correction of almost all the bone deformities in upper and lower limbs and in the foot.

KNOW MORE
  1. National Institute of Neurological Disorders and Stroke. Charcot-Marie-Tooth Disease: Fact Sheet. Bethesda, MD: National Institutes of Health; 2015. http://www.ninds.nih.gov/disorders/charcot_marie_tooth/detail_charcot_marie_tooth.htm [Accessed October 2015].
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ORTHOFIX SOLUTIONS

The Agile Nail is intended for insertion in the medullary canal of a femur for the alignment and the stabilization of fractures and for the correction of deformities. It is indicated for the treatment of subtrochanteric fractures and of femoral shaft fractures, in pediatric patients, with the exception of newborns and infants, and in adult patients with an appropriate medullary canal. The indications include:

  • Prophylactic nailing of impending pathologic fractures;
  • Fixation of femurs that have been surgically prepared (osteotomy);
  • Non-unions and malunions;
  • Reconstruction following tumor resection and grafting and bone lengthening and shortening.

The Orthofix Ankle Hindfoot Nailing (AHN) System is intended to facilitate tibiotalocalcaneal arthrodesis (fusion). Specific indications include:

  • Avascular necrosis of the talus
  • Failed total ankle arthroplasty
  • Trauma (malunited tibial pilon fracture)
  • Severe deformity or instability as a result of talipes equinovarus, cerebral vascular accident, paralysis or other neuromuscular disease
  • Revision ankle arthrodesis
  • Neuroarthropathy
  • Rheumatoid arthritis
  • Osteoarthritis
  • Pseudoarthrosis
  • Post-traumatic arthrosis
  • Previously infected arthrosis
  • Charcot foot
  • Severe endstage degenerative arthritis
  • Severe defects after tumor resection
  • Pantalar arthrodesis

INTENDED PURPOSE
The Guided Growth Plate Systems are plates intended to provide bone fixation.

INDICATIONS FOR USE
The Guided Growth Plate Systems are indicated for gradually correcting deformities of long bones in growing children. Specific acquired or congenital patterns of bone deformity for which the device will be indicated include:
• Valgus, varus or flexion, extension deformities of the knee (femur and/or tibia);
• Valgus, varus, or plantar flexion deformities of the ankle.

Fitbone is an intramedullary lengthening system for limb lengthening of the femur and tibia.

The G-Beam Fusion Beaming System is intended to be inserted in the bones of the foot and ankle for alignment, stabilization and fixation of various fractures and osteotomies, fusions and reconstructions. It is indicated for fracture and osteotomy fixation, reconstruction procedures, non-unions and fusions of bones of the foot and ankle including metatarsals, cuneiforms, cuboid, navicular, calcaneus and talus. Specific example: medial and lateral column fusions resulting from neuropathic osteoarthropathy (Charcot osteoarthropathy).

The JuniOrtho Plating System is indicated for internal fixation and stabilization of femoral and tibial fractures, osteotomies, mal-unions and non-unions. Indications include:

  • Varus, valgus, rotational and/or shortening osteotomies
  • Femoral neck and/or pertrochanteric fractures
  • Proximal and distal metaphyseal fractures
  • Pathological and impeding pathological fractures

Use of the JuniOrtho Plating System is indicated in pediatric (excluding newborns) and small stature adult patients.

Indications:

  • Short Stature
  • Bone loss
  • Open fractures​
  • Non-union
  • Angular deformities

Indications:

  • Metacarpal and metatarsal lengthening
  • Calcaneal lengthening
  • Pediatric forearm lengthening
  • Metacarpal, metatarsal and phalangeal lengthening
  • Joint arthrodesis
  • Joint stiffness; Comminuted intra-articular fractures
  • Soft tissue correction in patients with neurological disorders (e.g. cerebral palsy)
  • Arthrodesis of the 1st carpo-metacarpal joint following soft tissue correction
  • Complex upper extremity deformities
  • Hand contractures
  • Wrist contractures
  • Indicated for pediatrics through adult

INTENDED PURPOSE

The SOLE™ Medial Column Fusion Plate (SOLE MCF) is intended to provide bone fixation.

INDICATIONS FOR USE

The SOLE MCF is indicated for orthopedic applications within the anatomical area of the foot and ankle, including but not limited to the medial column (consisting of the first metatarsal, medial cuneiform, navicular and talus). Specific indicated procedures include:

  • Arthrodesis
  • Joint depression stabilization
  • Fracture and/or osteotomy fixation
  • Reconstruction
  • Revision

to be performed for conditions such as Charcot neuroarthropathy.

The TL-HEX system is intended for limb lengthening by metaphyseal or epiphyseal distractions, fixation of open and closed fractures, treatment of non-union or pseudoarthrosis of long bones and correction of bony or soft tissue defects or deformities.

INDICATIONS:

  • Fractures
  • Non-unions/ malunions
  • Limb lengthening
  • Deformity corrections
  • For pediatrics, the same indications apply provided a growth plate is not compromised

“www.limbhealing.com”
This website is for educational purposes only and is not a substitute for a consultation with your physician or health care professional. The information provided herein is a service and should be viewed only as opinion. The information contained herein has been obtained from sources deemed ethical and reliable, but completeness is not guaranteed.

ALWAYS SEEK THE ADVICE OF YOUR PHYSICIAN OR OTHER QUALIFIED HEALTH CARE PROFESSIONAL ABOUT DIAGNOSIS AND TREATMENT INFORMATION.

This site is intended for U.S. patients and their caregivers.

CONTACT

ORTHOFIX MEDICAL INC.
3451 Plano Parkway
Lewisville, TX 75056
USA

Phone: 214.937.2000
Email: [email protected]

Full prescribing information can be found in product labeling.

Caution: Federal law (USA) restricts this device to sale by or on the order of a physician.

© 2022 Orthofix Srl
Agile Nail™, Ankle Hindfoot Nailing System™, eight-Plate Guided Growth System™, eight-Plate Guided Growth System+™, Fitbone™, G-Beam™, JuniOrtho™ Plating System, LRS Advanced™, Minirail™, SOLE™ Medial Column Fusion Plate, TL-HEX TrueLok Hexapod System™ are trademarks or registered trademarks of Orthofix S.r.l. TrueLok is a trademark or registered trademark exclusively licensed to Orthofix Medical Inc., and its affiliate companies. The relevant short forms, as indicated in brackets next to each registered trademark, are also used alone as distinctive signs in the name and on behalf of Orthofix S.r.l. and are protected in accordance with the provisions set by the local Intellectual Property law.